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| First Name: | Benedict | | Last Name: | Albensi | | Title: | Associate Professor (Principal Invest) | | Advanced Degrees: | PhD | | Affiliation: | University of Manitoba | | Department: | Pharmacology and Therapeutics | | Street Address 1: | 351 Tache Ave/Lab 4050 | | Street Address 2: | St Boniface Research Centre | | City: | Winnipeg | | State/Province: | Manitoba | | Zip/Postal Code: | R2H 2A6 | Country/Territory: | Canada | | Phone: | 204/235-3942 | | Email Address: |  |
Disclosure:
(view policy)
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Member reports no financial or other potential conflicts of interest. [Last Modified: 19 January 2013]
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Aging Process, Alzheimer Disease, Stroke and Trauma
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Molecular and Cell biology, Neuropathology, Signal transduction, Electrophysiology, Genetics, Apoptosis/Cell cycle, Clinical trials, Oxidative Stress, Proteomics, Synaptic plasticity, Neurobiology, Chemistry/Pharmacology, Tau/Cytoskeleton, Microscopy, Drug screening, Diagnosis, DNA microarrays, A-beta PP/A-beta, Neurotransmission, Brain imaging, Animal Models
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Research institute, Medical hospital, University
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My laboratory is focused on understanding the biological basis of memory. In addition, we study NF-kB signaling pathways that play a roll not only in normal memory, but also in Alzheimer's disease. Current and/or Past manuscripts/studies include:
* The role of creatine and mitochondrial dysfunction in memory impairment in AD
* NF-kB p50 subunit knock out leads to impairments in LTP and memory (MWM)
* The role of presenilin mutations in synaptic plasticity and Alzheimer's disease
* Hypoxia-ischemia in the neonatal vs. adult hippocampus
* Temporal evolution of traumatic brain injury (TBI) in the adult hippocampus
* Distribution of N-type calcium channels in human and rat hippocampus
* Mitochondrial membrane permeability transition, TBI, and hippocampal synaptic plasticity
* Tumor necrosis factor and hippocampal synaptic plasticity
* Spider toxins, NMDA/AMPA-receptor mediated transmission, and hippocampal synaptic plasticity
* Suppression of epileptiform activity by prolonged electrical stimulation in the hippocampus
Prior investigations have also attempted to identify therapeutic targets (glutamate receptors, oxidative stress intermediates, cytokines, and ionic channels) in CNS diseases and pathology such as in dementia, stroke, head trauma, and processes of aging, etc. This has included work with natural products for drug discovery.
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B.C. ALBENSI and M.P. Mattson. Evidence for the Involvement of TNF and NF-kB in Hippocampal Synaptic Plasticity. Synapse 35: 151-159, 2000.
B.C. ALBENSI, S. Knoblach, B.G.M. Chew, M.P. O'Reilly, A.I. Faden and J.J. Pekar. Diffusion and High Resolution MRI of Traumatic Brain Injury in Rats: Time Course and Correlation with Histology. Exp Neurol 162: 61-72, 2000.
B.C. ALBENSI, P. Sullivan, M. Thompson, S. Scheff and M.P. Mattson. Cyclosporin Ameliorates Traumatic Brain Injury-Induced Alterations of Hippocampal Synaptic Plasticity Exp Neurol 162(2):385-389, 2000.
N. Marchi, P. Rasmussen, M. Kapural, V. Fazio, K. Kight, M.R. Mayberg, A. Kanner, B. Ayumar, B.C. ALBENSI, M. Cavaglia, D. Janigro. Peripheral markers of brain damage and blood-brain barrier dysfunction. Restor Neurol Neurosci 21(3,4):109-121, 2003
B.C. ALBENSI, E. Ilkanich, G. Dini and D. Janigro. Elements of Scientific Visualization in Basic Neuroscience Research. BioScience 54(12): 1127-1137, 2004. Review.
J. Thiessen, K.A.C. Glazner, S. Nafez, A. Schellenberg, R. Buist, M. Martin, and B.C. ALBENSI. Histochemical visualization and diffusion weighted imaging in the TgCRND8 transgenic model of Alzheimer’s disease. Brain Structure and Function 215(1): 29-36, 2010.
D. Zhang, R. Buist, W. Xiong, J. Peeling, B.C. ALBENSI, F.E. Parkinson. Expression of human equilibrative nucleoside transporter 1 (hENT1) in mouse neurons regulates adenosine levels in physiological and hypoxic-ischemic conditions. Journal of Neurochemistry 118(1):4-11, 2011.
M.Z. Kastyak-Ibrahim, M.J. Nasse, M. Rak, C. Hirschmugl, M.R. Del Bigio, B.C. ALBENSI and K.M. Gough. Biochemical label-free tissue imaging with subcellular-resolution synchrotron FTIR-FPA. NeuroImage 60: 376–383, 2012.
K. Oikawa, G.L. Odero, E. Platt, M. Neuendorff, A. Hatherell, M.J. Bernstein, and B.C. ALBENSI. NF-kB p50 Subunit Knockout Impairs Late LTP and Alters Long Term Memory in the Mouse Hippocampus. BMC Neuroscience 13:45, 2012. Noted as “Highly Accessed” by publisher on Oct 10, 2012 (989 times).
D. Zhang, S. Chu, C. Sun, W. Xiong, B.C. ALBENSI, F. E. Parkinson. Inhibition of synaptic activity in hippocampus by ATP, hypoxia or oxygen-glucose deprivation does not require CD73. PloS One. Accepted May 2012 (PONE-D-12-08114R1).
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One very important pathological consideration is the link between Amyloid beta deposition and the hyperphosphorylation of tau proteins that lead to tangles. We do not know how this occurs. |
1) how to improve mitochondrial function and cellular energetics
2) how to reduce inflammatory respones in AD
3) how to reduce oxidative stress |
The most interesting hypothesis of late in my mind has to do with deficits in cellular energetics and the establishment of AD. |
If we could reverse cognitive deficits by improving mitochondrial function over the long term. |
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